We have previously discussed three trials from the early ‘90s. This list continues the theme by focusing on other studies conducted around that time.
ATLANTIS A
This trial evaluated the administration of tPA across several time windows from 0-6 hours. The primary result compared proportions of patients with a 4-point or greater improvement at 30 days and at the moment of presentation.
Researchers noted a 15% absolute difference favoring the placebo arm. There were also statistically significant absolute increases in mortality and symptomatic ICH among tPA recipients.
ATLANTIS B
This was an …
